Journal article
No Influence of Age-Related Hearing Loss on Brain Amyloid-β
JZ Sarant, DC Harris, PA Busby, C Fowler, J Fripp, CL Masters, P Maruff
Journal of Alzheimer S Disease | Published : 2022
DOI: 10.3233/jad-215121
Abstract
Background: Hearing loss is independently associated with a faster rate of cognitive decline in older adults and has been identified as a modifiable risk factor for dementia. The mechanism for this association is unknown, and there has been limited exploration of potential casual pathology. Objective: Our objective was to investigate whether there was an association between degree of audiometrically measured hearing loss (HL) and brain amyloid-β (Aβ) in a pre-clinical sample. Methods: Participants of the Australian Imaging and Biomarker Longitudinal Study (AIBL; n = 143) underwent positron emission tomography (PET) imaging and objective measurement of hearing thresholds within 5 years of ima..
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Awarded by Alzheimer's Association
Funding Acknowledgements
This study was supported by Australian Research Council Linkage grant LP150101180. The AIBL study has received partial financial support provided by the Alzheimer's Association (US), the Alzheimer's Drug Discovery Foundation, an Anonymous foundation, the Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government's Operational Infrastructure Support Program, the McCusker Alzheimer's Research Foundation, the National Health and Medical Research Council, and the Yulgilbar Foundation. Numerous commercial interactions have supported data collection and analysis.